A new approach to assessing intra-subject variability in single-subject designs

Controlling for Intra-Subject and Inter-Subject Variability in Individual-Specific Cortical Network Parcellations

Resting-state functional magnetic resonance imaging (rs-fMRI) offers the opportunity to noninvasively study brain networks within individuals. Previous individual-specific network mappings do not account for intra-subject (within-subject) variability. Therefore, intrasubject variability might be mistaken for inter-subject (between-subject) differences. Here we propose a multi-session hierarchic...

Improving the reliability of single-subject fMRI by weighting intra-run variability

At present, functional magnetic resonance imaging (fMRI) is one of the most useful methods of studying cognitive processes in the human brain in vivo, both for basic science and clinical goals. Although neuroscience studies often rely on group analysis, clinical applications must investigate single subjects (patients) only. Particularly for the latter, issues regarding the reliability of fMRI r...

Supplement for “ Bayesian Hypothesis Testing for Single - Subject Designs ”

This document provides example R code demonstrating how to use the BayesSingleSub package (Section 1), and the technical details for the sampling routines (Section 2). 1 Tutorial for computing de Vries and Morey's Bayes factors Here, we show how to compute the Bayes factors B ar , B trend , B int , and B t+i , and how to obtain and plot the posterior distributions of the model parameters. First...

JMASM 32: SAS Template for Single-Subject Experimental Designs

Descriptive Analysis of Single Subject Research Designs: 1983–2007

Single subject research methodology is commonly used and cited in special education courses and journals. This article reviews the types of single subject research designs published in eight refereed journals between 1983 and 2007 used to answer applied research questions. Single subject designs were categorized as withdrawal/reversal, time lagged, comparison, or combination designs. To analyze...